Which side effect is commonly observed with the use of antifungals?

Liver damage is a well-documented side effect associated with the use of many antifungal medications. Certain antifungals, such as azoles, can significantly impact liver function because they are metabolized by the liver. This metabolic process can lead to an increase in liver enzymes, indicating potential liver injury. Regular monitoring of liver function tests is advised for patients receiving antifungal treatment to catch any early signs of hepatotoxicity.

The other options listed are less commonly related to antifungal medications. For instance, while hypotension can occur in some contexts, it is not typically a direct side effect of antifungals. Anxiety and dry mouth are also not recognized as common side effects of these medications, making liver damage the most relevant and critical concern when using antifungal treatments.